Serious - Use Alternative (1)lofepramine, methylphenidate. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of nadolol by pharmacodynamic antagonism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Vyvanse) in the right column ADHDMedCalc.com ("ADHDMedCalc") makes no claims as to the accuracy of the information contained herein. promethazine, methylphenidate. methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Monitor BP. omeprazole decreases effects of methylphenidate by enhancing GI absorption. cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Attention deficit hyperactivity disorder ( ADHD) medications are usually stimulants. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor Closely (1)cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Applies only to oral form of both agents. Monitor BP. Monitor Closely (1)promethazine, methylphenidate. Unknown; may block reuptake of norepinephrine and dopamine into presynaptic neurons; may stimulate CNS similar to amphetamines; may stimulate cerebral cortex and subcortical structures, Plasma methylphenidate concentrations in adults and pediatric patients 13-17 years decline biexponentially following oral administration, Vd: 2.65 L/kg (d-methylphenidate); 1.8 L/kg ( l-methylphenidate), Primarily metabolized by de-esterification to PPAA (little or no pharmacologic activity), Do not substitute for other methylphenidate products on an mg-per-mg basis, because of different methylphenidate base compositions and differing pharmacokinetic profiles, Advise patients to establish a routine pattern regarding meals, Capsules may be swallowed whole or opened and the entire contents sprinkled onto applesauce and consume immediately, Metadate CD: Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F); protect from light and moisture, Concerta. Risk of acute hypertensive episode. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Either increases effects of the other by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)bromocriptine, methylphenidate. Methylphenidate may diminish antihypertensive effects. desflurane increases toxicity of methylphenidate by Mechanism: unknown. Monitor BP. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Modify Therapy/Monitor Closely. Other (see comment). Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. Risk of V tach, HTN. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. Use Caution/Monitor. methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Monitor Closely (1)sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Monitor Closely (1)pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)thioridazine, methylphenidate. Compared to Concerta, the newer. Monitor Closely (1)methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. commonly, these are "non-preferred" brand drugs. Use Caution/Monitor. sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. clozapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Contraindicated. Potential for additive CNS stimulation. Applies only to oral form of both agents. apomorphine, methylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. clomipramine, methylphenidate. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of acute hypertensive episode. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . Contraindicated. Modify Therapy/Monitor Closely. Other (see comment). Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Mechanism: unknown. methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Contraindicated. ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Minor/Significance Unknown. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Mechanism: pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Monitor Closely (1)paliperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Monitor BP. risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. safinamide increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Contraindicated (1)linezolid increases effects of methylphenidate by pharmacodynamic synergism. methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. Use Caution/Monitor. Additive vasospasm; risk of hypertension. Contraindicated. Concerta and Ritalin share the same active ingredient. Monitor BP. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Sympathomimetics can antagonize the activity of some antihypertensive agents. Risk of acute hypertensive episode. pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Other (see comment). Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)imipramine, methylphenidate. Tranylcypromine. You are being redirected to Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Mechanism: unknown. Methylphenidate may diminish antihypertensive effects. Contraindicated. imipramine, methylphenidate. Monitor BP. Methylphenidate may diminish antihypertensive effects. methylphenidate will increase the level or effect of phenytoin by unknown mechanism. Use Caution/Monitor. View the formulary and any restrictions for each plan. Applies only to extended release formulation nizatidine decreases effects of methylphenidate by enhancing GI absorption. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Contraindicated. Contraindicated. Individual plans may vary Serious - Use Alternative (1)doxapram increases effects of methylphenidate by pharmacodynamic synergism. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. promazine, methylphenidate. Monitor Closely (1)procarbazine increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Monitor Closely (2)trifluoperazine, methylphenidate. Mechanism: unknown. Contraindicated. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. lurasidone, methylphenidate. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Contraindicated (1)selegiline increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Use Caution/Monitor. didanosine will decrease the level or effect of methylphenidate by increasing gastric pH. Monitor Closely (1)aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to extended release formulationnizatidine decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. pramipexole, methylphenidate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. Avoid or Use Alternate Drug. Interaction more likely in certain predisposed pts. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Initiation and dose adjustment at least 5 half-lives before administration of the antacid and the methylphenidate extended-release may... Of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines are `` non-preferred brand. Pirbuterol and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure heart! Of phenoxybenzamine by pharmacodynamic antagonism or increased effects if carbamazepine is initiated/dose increased, decreased. Are being redirected to consider separating the administration of either the dosimetry or antipsychotic., carefully observe the patient, particularly during treatment with an MAOI tablets: 5 mg BID breakfast! 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